Fibromodulin Enhances Angiogenesis during Cutaneous Wound Healing
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چکیده
منابع مشابه
Fibromodulin Enhances Angiogenesis during Cutaneous Wound Healing
BACKGROUND Fibromodulin (FMOD) plays a critical role in the wound-healing process. Our previous studies revealed that FMOD deficiency led to marked alterations in adult wound healing characterized by delayed dermal cell migration, postponed wound closure, and increased scar formation, all accompanied by impeded angiogenesis. Therefore, the aim of this study was to reveal the effect of FMOD on a...
متن کاملAbstract 12: Fibromodulin Selectively Promotes Myofibroblast Apoptosis During Cutaneous Wound Healing
METHODS: A resected VM specimen was digested and cells sorted with CD133+ magnetic beads. Isolated cells were analyzed by FACS with antibodies against endothelial progenitor markers, inflammatory cell markers, and differentiated EC markers. Cells were re-suspended in Matrigel and injected into an immunocompromised mouse. After 3 weeks, implants were harvested and stained with an antibody agains...
متن کاملCOMP-angiopoietin 1 Gene Transfer Enhances Cutaneous Wound Healing by Promoting Angiogenesis.
BACKGROUND Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered angiogenic factor and there have been few studies of its effect on cutaneous wound healing. OBJECTIVE We examined the effect of Ang 1 on cutaneous wound healing. METHODS Cartilage oli...
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A simple model of wound healing angiogenesis is presented, and investigated using numerical and asymptotic techniques. The model captures many key qualitative features of the wound healing angiogenic response, such as the propagation of a structural unit into the wound centre. A detailed perturbative study is pursued, and is shown to capture all features of the model. This enables one to show t...
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P311 was identified to markedly promote cutaneous wound healing by our group. Angiogenesis plays a key role in wound healing. In this study, we sought to define the role of P311 in skin wound angiogenesis. It was noted that P311 was expressed in endothelial cells in the dermis of murine and human skin wounds. The expression of P311 was confirmed in cultured murine dermal microvascular endotheli...
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ژورنال
عنوان ژورنال: Plastic and Reconstructive Surgery Global Open
سال: 2014
ISSN: 2169-7574
DOI: 10.1097/gox.0000000000000243